Cytokines levels in bitches with pyometra submitted to OHE

23 April 2018 – News

Cytokines levels in bitches with pyometra submitted to OHE

A pyometra is characterized by the proliferation of opportunistic bacteria leading to inflammation and to a gradual build-up of pus within the uterine lumen. This condition is commonly seen in adult, intact, female dogs, and can be a life-threatening disorder, since affected animals are at risk of sepsis.
Pro and anti-inflammatory cytokines are molecules released to mediate and balance the acute phase of the inflammatory process. Interleukin 6 (IL6) enhances inflammation and increased levels of this molecule in dogs indicate that an inflammatory response was triggered. Interleukin 10 (IL10), on the other hand, inhibits immune response and inflammation.
In this study, researchers measured and compared the levels of serum IL-6 and IL-10 between two groups of dogs: 16 bitches with pyometra going through ovariohysterectomy (OHE), and a control group of 11 healthy dogs being submitted to elective OHE.
The levels of IL-6 and IL-10 were higher in bitches with pyometra when compared to the control group. The group of healthy dogs presented elevated concentrations of these cytokines 3 days after the surgery was performed, and a drop in these levels 10 days after the procedure. According to their results, the levels of IL-6 and IL-10 diminish after the uterus is surgically removed and after the body’s natural healing process. The authors propose that cytokine measurements can be helpful to monitor the postoperative period in bitches.

In Dąbrowski R, Pastor J, Szczubiał M, et al. Serum IL-6 and IL-10 concentrations in bitches with pyometra undergoing ovariohysterectomy. Acta Veterinaria Scandinavica. 2015;57:61. doi:10.1186/s13028-015-0153-8.