Effect of pimobendan on the cardiac rhythm and selected echocardiographic parameters of healthy cats

11 October 2021 – News

Effect of pimobendan on the cardiac rhythm and selected echocardiographic parameters of healthy cats

The effects of pimobendan on the heart rhythm in cats are unknown. The purpose of this pilot study is to evaluate the effect of pimobendan on cardiac rhythm and selected echocardiographic parameters of the cat.
To carry out this study, six clinically healthy cats received each four medication protocols for 15 days, with a washout period of at least one month between each protocol. The protocols were: Pimobendan 0.5 mg/kg twice daily (high dose group); Pimobendan 0.25 mg/kg twice daily (standard dose group); Pimobendan 0,125 mg/kg twice daily (low dose group (LD); Biofermin R, one tablet twice daily (placebo group).

Twenty-four-hour ambulatory electrocardiogram recordings, blood pressure measurements, and echocardiographic examinations were performed after two weeks of each medication protocol. Electrocardiographic, echocardiographic, and blood pressure parameters were compared between the four groups.

The results obtained were as follows: the total number of escape/ idioventricular/ idiojunctional complexes in the high-dose group was significantly higher compared with the placebo, low-dose, and standard-dose groups (p < 0,001). Blood pressure, total number of heartbeats per day and the mean, minimum, and maximum heart rates were not significantly different between the groups. In ultrasound, the degree of longitudinal deformation and calculated cardiac output increased significantly in the high and standard dose groups. The conclusion was that the administration of pimobendan, especially at high doses, was associated with a greater number of escape/ idioventricular/ idiojunctional complexes in some cats. Further studies are needed to investigate both the mechanism underlying the observed changes and what clinical implications these changes might have in cats with heart disease.

Fujii Y, Sugimoto K, Omichi M, Kanai K, Orito K. A pilot study investigating the effect of pimobendan on the cardiac rhythm and selected echocardiographic parameters of healthy cats. J Vet Cardiol. 2021 Jun;35:74-83. doi: 10.1016/j.jvc.2021.03.005. Epub 2021 Mar 24. PMID: 33887666.

Copyright © 2021 Elsevier B.V. All rights reserved.